صحة وجمال

Flazol – Metronidazole Tablets / Oral Suspension

145

Composition

  • Each film coated tablet contains 500 mg Metronidazole.
  • Each 5 ml oral suspension contains Metronidazole Benzoate equivalent to 125 mg Metronidazole.

    • Properties

    Flazol is a brand name of metronidazole tablets and metronidazole benzoate oral suspension. Metronidazole is 5-nitroimidazole derivative readily absorbed from the gastrointestinal tract and widely distributed into most body tissues and fluid. Metronidazole is active against anaerobic bacteria and protozoa.

    Indications

  • Intestinal giardiasis.
  • Non-specific vaginitis.
  • Anaerobic bacterial infections.
  • Acute ulcerative gingivitis and acute dental infections.
  • Surgical infection prophylaxis.

    • Contraindications

    Flazol is contraindicated in patients with known hypersensitivity to any of its components.

    Precautions

    Use cautiously in patients with history of blood dyscrasia, central nervous system (CNS) disorder, hepatic disease and in those receiving hepatotoxic drugs.

    Interaction with other drugs

  • Metronidazole enhances coumarol and warfarin anticoagulant effect.
  • Metronidazole increases phenytoin plasma concentration by inhibiting its metabolism.
  • Barbiturates reduce the metronidazole plasma concentration by accelerating its metabolism.
  • Cimetidine increases metronidazole plasma concentration by inhibiting its metabolism.
  • Metronidazole may increase lithium toxicity

    • flazol tablets 500 mg

    Warnings

    Use of metronidazole should be avoided during first trimester of pregnancy and during lactation.

    Dosage and Administration

    Amoebiasis: Adults: 500 mg 3 times daily -Children: 35 to 50 mg/kg/day in 3 divided doses for 7 to 10 days.

    Intestinal giardiasis: Adults: 1 g daily as single dose or two divided doses for 5 to 7 days Children: 15 mg/kg/day in two divided doses for 5 to 7 days. A second treatment is advisable after 10 days interval.

    Trichomoniasis: 2 gram as a single dose. Sexual partners should be treated concurrently.

    Non-specific vaginitis: 500 mg twice daily for 7 days. Sexual partners should be treated concurrently.

    Anaerobic bacterial infections : Adults: 1 g to 1.5 g per day for 5 to 7 days Children: 20 to 30 mg/kg/day for 5 to 7 days.

    Acute ulcerative gingivitis and acute dental infections: 250 mg 3 times daily for 3 days.

    Surgical infection Prophylaxis: Adults: 500 mg every 8 hours started 24 hours before surgery. Children: 7.5 mg/kg every 8 hours started 24 hours before surgery.

    Overdosage

    Overdosage of metronidazole may produce nausea, vomiting, ataxia, seizures and peripheral neuropathy. Induced emesis or gastric lavage is indicated. Activated charcoal and a cathartic may be used. Supportive therapy like diazepam or phenytoin may be used to control seizures.

    flazol suspension

    Side Effects

    Nausea, vomiting, diarrhea, metallic taste, rashes, urticaria, angioedema, headache and dizziness may occurs. On prolonged or intensive therapy: peripheral neuropathy, transient epileptic seizure and leucopenia may occur. Consult your physician or pharmacist if any side effect is observed.

  • Pharmaceutical Precautions
  • Keep at room temperature (15-30 °C).
  • Shake well the oral suspension before use.
  • Do not use beyond the expiry date or if the product shows any sign of deterioration.

    • فلازول 500 مجم حبوب


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