Glomox is a Broad-Spectrum Antibiotic. Glomox is Amoxicillin as( amoxicillin trihydrate), it is available in the following dosage form:① Capsules ②Suspension ③ Dispersible Tablets ④Tablets.

Glomox (amoxicillin) is a broad-spectrum aminopenicillin with a bactericidal activity against a wide range of Gram-negative and Gram-positive bacteria including: 

Streptococcus spp.

Stapylococcus (methicillin-sensitive).

Haemophilus influenzea (non beta-lactamase- producing strains).

Escherichia coll. 

Proteus mirabilis.

Salmonella spp.

Neisseria spp. 

Glomox Amoxicillin

Indications

Glomox is indicated for treatment of infection caused by susceptible organisms involving:

Urinary-tract infection.

Otitis media.

Sinusitis.

Bronchitis.

Haemophilus influenzae.

Skin and soft tissue infections.

Invasive salmonellosis.

Gonorrhoea. 

Glomox is also indicated for prophylaxis of bacterial endocarditis in patients undergoing surgical or dental procedures.

Glomox is also used in combination with clarithromycin and omeprazole for eradication of Helicobacter pylori, in patients with active duodenal ulcer disease or a 1-year history of duodenal ulcer.

Dosage and Administration

Glomox may be administered without regard to meals.Glomox Dispersible tablets should first stirred well in half a glass of water and then taken.

Adults Dosage

Adults: 250 to 500 mg every 8 hours. 

Short-course therapy:

Dental abscess 3 gram repeated after 8 hours.

Urinary- tract infections: 3 gram repeated after 10 to12 hours.

Uncomplicated gonorrhoea: 2 to 3 gram plus probenecid 1 gram in a single dose.

Endocarditis prophylaxis: 3 gram 1 hour before surgical procedures.

Helicobacter pylori: 1 gram twice/day. Clinically effective treatment regimens include triple therapy with:

amoxicillin, metronidazole, and bismuth subsalicylate.

or amoxicillin, metronidazole, and an H2-receptor antagonist.

or amoxicillin, omeprazole, and clarithromycin.

Children Dosage 

Children: 20 to 50 mg/Kg/day in divided doses every 8 hours.

Uncomplicated gonorrhoea: ≥ 2 years: 50 mg/kg plus probenecid 25 mg/kg in a single dose. This regimen is not recommended in children < 2 years of age. probenecid is contraindicated in this age group.

Subacute bacterial endocarditis prophylaxis: 50 mg/Kg 1 hour before procedure.

Dosage in Renal Impairment

Dosage adjustment should be based on creatinine clearance: 

Moderate impairment (Creatinine clearance 10 to 50 ml/min): Administer every 12 hours. 

Severe impairment (Creatinine clearance < 10 ml/min): Administer every 24 hours.

Precautions

Glomox should be used with care in patients with moderate or severe renal impairment.Doses and/ or frequency of administration should be modified in response to the degree of renal impairment. 

Patients with infectious mononucleosis may develop rash during therapy with amoxicillin. 

Glomox should also be used with caution in patients with a history of allergy, chronic lymphatic leukaemia and possibly with HIV infection.

Use in Pregnancy and Lactation

As with all medicines Glomox should be used during pregnancy only if clearly needed.

Amoxicillin is excreted in breast milk (in small amounts) and should be used with caution in lactating mothers.

Side Effects

Glomox is well tolerated. Side effects are uncommon and mainly of mild and transit nature.The reported adverse effects may include:

Nausea.

Vomiting.

Diarrhoea.

Rarely antibiotic-associated colitis.

Indigestion.

Occasional rash, either urticarial, which suggests penicillin hypersensitivity, or erythematous.

Erythematous rash may occur in patients with glandular fever. in which case it is advisable to discontinue treatment.

Patient Information Leaflet

Glomox Patient Information Leaflet

Presentation

Glomox 250 mg Capsules. 

Glomox 500 mg Capsules. 

Glomox 1000 mg Tablets.

Glomox 125 DT tablets.

Glomox 250 DT tablets.

Glomox 125 mg/5ml in bottles of 100 ml. 

Glomox 250 mg/5ml in bottles of 100 ml. 

Note: presentations may not all be available in some countries. Categories and Tags: J01CA04, Amoxicillin, Penicillins with extended spectrum, BETA-LACTAM ANTIBACTERIALS, PENICILLINS, ANTIBACTERIALS FOR SYSTEMIC USE, ANTIINFECTIVES FOR SYSTEMIC USE.