Pethidine is a drug with powerful pain relieving properties. Pethidine injection is used for the Relief of moderate to severe pain and is used for pain relief during labour. It may also be used to stop you from feeling pain before and during an operation and to provide continuous pain relief if needed.

Pethidine Injection

Before you are given Pethidine Injection

You should not be given injection if: 

you are allergic (hypersensitive) to Pethidine Hydrochloride or to any of the ingredients of this medicine.

you suffer from asthma, shallow breathing or other breathing difficulties 

you are suffering from severe headaches or have suffered a head injury 

you suffer from alcoholism

you suffer from a convulsive disorder (fits) such as epilepsy 

you have any liver or kidney problems 

you are suffering from a condition known as delirium , caused by Withdrawal from alcohol 

your heartbeat is faster than usual 

you suffer from a tumour of the adrenal gland known as pheochromocytoma.

phaecchrornccytoma 

you suffer from diabetes 

you are taking or have recently taken any drugs used to treat depression known as Monoamine Oxidase Inhibitors( MAOIs).

Take special care with Pethidine Injections

Tell your doctor if you: 

are in shock, the symptoms of which include sweating, a fast pulse and cold, clammy skin 

suffer from thyroid problems 

suffer from problems related to your adrenal gland (the organ responsible for stress levels), including adrenocortical insufficiency (a lack of the hormones produced by the adrenal gland) 

suffer from low blood pressure 

suffer from problem with your prostate 

suffer from problems with your gallbladder 

suffer from problems with your bowel 

If you are elderly or ill, or your baby or child is being given Pethidine Injection, special care will be taken. 

If any of the above apply to you or your child, please tell your doctor before being given Pethidine Injection. 

Taking other medicines

Please tell your doctor, nurse or midwife if you are taking, or have recently taken, any other medicine including medicines obtained without prescription. 

Pethidine Injection must not be used with drugs used to treat severe depression, such as rasagiline or moclobemide, or if you are within 2 weeks of discontinuing them.These drugs are known as Monoamine Oxidase Inhibitors (MAOIs).

Other medicines which may interact with Pethidine Injection include: 

selegiline, a medicine used to treat Parkinson’s disease 

ritonavir, a medicine used to treat HIV.

cimetidine, a medicine used to treat stomach ulcers .

medicines used to reduce anxiety (anxtolytlcs.

medicines used to help you to sleep(hypnotics).

CNS depressants (drugs that act on the brain and make you feel drowsy or faint). These include sleeping pills,antihistamines(medicines used to treat allergy) that make you drowsy medicines used to treat certain mental disorders, other pain killers or a general anaesthetic.

phenytoin, a medicine used to treat fits.

medicines used to treat serious mental disorders(phenothiazines) 

duloxetine, a rned.clne used to treat depression 

If you are in any doubt please tell your doctor of any medication you are taking. 

Pregnancy and breastfeeding

If you are pregnant, think you may be pregnant or you are breastfeeding, you should consult your doctor before having Pethidine Injection. 

Pethidine can pass into your baby either through your blood :during pregnancy and labour or through your breast milk. This can cause breathing problems in newborn babies .Your doctor will be aware of this and will correct the problem and discuss feeding with you.

Driving and using machines

This medicine can affect your ability to drive and operate machinery. Do not drive or operate machinery if you feel drowsy or cannot think clearly.This medicine can affect your ability to drive and operate machinery as it may make you sleepy or dizzy. 

Do not drive while taking this medicine until you know how it affects you. 

It is an offence to drive if this medicine affects your ability to drive. 

However, you would not be committing an offence if: 

The medicine has been prescribed to treat a medical or dental problem and 

You have taken it according to the instructions given by the prescriber or in the information provided with the medicine and 

It was not affecting your ability to drive safely 

Talk to your doctor or pharmacist if you are not sure whether it is safe ‘for you to drive while taking this medicine. 

Having Pethidine Injection with food ,and drink 

You are advised not to drink alcohol during your treatment with 

this medicine.

How Pethidine Injection will be given 

Your doctor will give Pethidine Injection to you as an injection into a vein (intravenously), under the skin (subcutaneously) or into a muscle (lntrarnuscularly). Your doctor will determine how much you need.

Adults dosage- For the relief of moderate to severe pain: 

The usual initial dose is 25 100 mg either into a muscle or under the skin, or 25 50 mg if given into a vein. The dose is given at a minimum of four hourly intervals if needed. 

Adults dosage- For pain relief during labour: 

The usual dose is 50 100 mg either into a muscle or under the skin every 1-3 hours during labour up to a maximum of 400mng in 24 hours. 

Adults dosage- For pain relief before and during an operation: 

The usual dose is 50 100 mg into a muscle one hour before the operation. 

Adult dosage- For continuous pain relief: 

The usual dose is 10 25 mg  by slow injection into the vein as needed. 

The elderly and ill dosage

It is recommended that a reduced dose be used. The usual initial dose is up to a maximum of 25 m.

Children dosage- For the relief of moderate to severe’ pain: 

The usual dose is 10 25 mg per kilogram of body weight by intramuscular injection. 

Children dosage- For pain relief before and during an operation: 

The usual dose is 1 2 mg per kilogram of body weight into the muscle one hour before the operation. 

possible Side Effects 

like all medicines Pethidine injection can cause side effects, although not everybody gets them. 

Repeated  use of Pethidine  can result in tolerance and addiction 

 If any’ of the following symptoms occur contact your doctor or nearest accident and emergency department immediately. These are symptoms of a serious allergic reaction. 

sudden wheezing and tightness of chest 

swelling of eyelids, face or lips ” skin lumps or hives 

skin rash ,Red spots, itchiness, fever .

collapse 

Other side effects that may occur.include: 

restlessness 

drowsiness 

constipation 

dry mouth 

feeling sick (nausea) 

being sick (vomiting) 

facial flushing 

sweating 

a fast or slow heartbeat 

palpitations (and irregular heart rhythm or missed beats )

low blood pressure, the symptoms of which include feeling dizzy or light·headed, feeling weak and fainting. 

high blood pressure 

pin-point pupils 

a feeling of dizziness or spinning 

fainting 

feeling weak 

hallucinations (seeing or hearing things that aren’t real) 

mood changes.

headache

feeling faint on standing up from a seated position.

slow breathing 

red, itchy rash.

reduced sex drive.

difficulty achieving or maintalnno an erection

pain, redness or itching at the injection site

hypothermia, the symptoms of which include shivering, drowsiness and feeling weak 

feeling’ of intense happiness(euphoria) 

difficulty in passing urine 

spasms in the lower abdomen .#Narcotic_drugs

Pethidine Product Gallery

Pethidine 50 mg in 1 ml ampoules

Pethidine 50 mg in 1 ml Ampoules by ROCHEPethidine Hameln 50 mg in 1 mg ampoules by hameln

Pethidine 100 mg in 2 ml ampoules

Pethidine 100 mg in 2 ml Ampoules

حقن بيثيدين- معلومات باللغة العربية

Pethidine Injection technical prescribing information

For the full information , read Patient information leaflet.

Pethidine Patient Information Leaflet