Composition
Each 5 g (sachet) contains:
Inactive Ingredients: Sed.Bicarbonate, Citric acid anhy., Tartaric acid, P.V.P, Lemon oil, Sucrose.
Pharmacological action
An acute attack of gout apparently occurs as a result of increasing uric acid concentration that results in deposition of monosodium urate in the joint tissue. Piperazine known for many years to be an active drug in the treatment of gout and urinary lithiasis. increase the solubility of urates in the urine. It is relatively non-toxic.
Colchicine gives rapid relief from pain in acute attacks of gout and the drug is specific for this condition to the extent that it can be used as a diagnostic agent in gout and gouty arthritis. Colchicine possesses anti-inflammatory properties. Although it is highly effective in treating acute gouty arthritis, it is not effective for other types of pain. It is not of neutrophils.
an analgesic and does not affect uric acid clearance. Instead,colchicine binds to proteins in microtubules This binding,in turn, inhibits the migration of neutrophils into the area of inflammation, thereby interfering with the inflammatory response to urate crystal deposition. Atropine sulphate is added to relieve the spasm of the urinary tract.
Pharmacokinetics
Urosolvine contains a typical uricosuric agent that promotes the urinary excretion of uric acid and thereby lower -Sodium citrate is an alkalinising agent since the citrate is converted into bicarbonate, alkaline urine is definitely more serum uric acid concentration suitable for the excretion of urates in a more soluble form.
Indications
Dosage and administration
Contraindications
Side effects
Occasionally nausea, vomiting,abdominal pain and diarrhea may occur.
Drug interactions
None.
Pregnancy and lactation
Precautions and warnings
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