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Amrizole: A Powerful Antiprotozoal and Bactericidal Medication

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Amrizole: A Powerful Antiprotozoal and Bactericidal Medication

Amrizole is a medication known for its potent antiprotozoal and bactericidal properties. It contains the active ingredient metronidazole, which is highly effective in treating various anaerobic infections and protozoal diseases. In this blog post, we will explore the composition, properties, indications, dosage, side effects, and other essential information about Amrizole.

Composition and Properties

Amrizole comes in two forms:

  1. Suspension: Each 5 ml of the suspension contains 200 mg of 2-(2-Methyl-5-nitroimidazole-1-yl) ethyl benzoate, which is equivalent to 125 mg of metronidazole.
  2. Tablet: Each tablet contains 250 mg of metronidazole in the form of 2-(2-Methyl-5-nitroimidazole-1-yl) ethanol.

The active principle in Amrizole, metronidazole, exhibits strong antiprotozoal and bactericidal actions. It is particularly effective against anaerobic infections involving conditions such as septicaemia, necrotising pneumonia, puerperal sepsis, pelvic abscesses, cellulitis, and postoperative wound infections. Additionally, Amrizole is known to combat infections caused by “Trichomonas vaginalis” and other protozoa like “Entamoeba histolytica” and “Giardia lamblia.”

Indications for Use

Amrizole is primarily indicated for the treatment of the following conditions:

  • Trichomoniasis of the genitourinary tract in males and females.
  • Amoebiasis, including amoebic dysentery and amoebic liver abscesses.
  • Eradication of “E. histolytica” from patients passing cysts.
  • Prevention and treatment of anaerobic infections in patients undergoing abdominal and gynaecological surgery.
  • Treatment of giardiasis and Vincent’s infection.

    • Dosage Guidelines

    The dosage of Amrizole varies depending on the condition being treated and the age of the patient:

    Treatment of Amoebiasis

  • Adults: 1-2 tablets three times daily for 5-10 days
  • Children (5-12 years): ½-1 tablet three times daily for 5-10 days.
  • Adults (suspension): 2-4 teaspoonfuls three times daily for 5-10 days.
  • Children (up to 3 years): 6-1 teaspoonful three times daily for 5-10 days.
  • Children (3-7 years): 1 ½ 1 ¾ teaspoonful three times daily for 5-10 days.
  • Children (7-10 years): 1-2 teaspoonfuls three times daily for 5-10 days.

    • Treatment of Trichomoniasis

  • Adults: One tablet three times daily for 7 days. A second course of treatment may be given, if needed, after an interval of 4 to 6 weeks. The concomitant treatment of sexual consorts is recommended.
  • Children (up to 3 years): 1 ¼ teaspoonful daily for 7 days.
  • Children (3-7 years): 1½ teaspoonful daily for 7 days.
  • Children (7-10 years): 2½ teaspoonfuls daily for 7 days.

    • Treatment of Giardiasis

  • Adults: One tablet three times daily for 10 days.
  • Children: Proportional to the dosage used for amoebiasis.

    • Prevention and Treatment of Postoperative Anaerobic Infections

  • Adults: 1-2 tablets three times daily for 7 days.
  • Children: 2-4 teaspoonfuls three times daily for 7 days.

    • Side Effects

    Amrizole is generally well-tolerated, but some individuals may experience mild side effects, including:

  • Flatulence
  • Mild gastric upset

    • However, patients with blood dyscrasias or active central nervous system disease should not use metronidazole. It is also advisable to avoid its use during pregnancy.

    Contraindications and Drug Interactions

    Amrizole should not be used in patients with blood dyscrasias or active central nervous system disease. Additionally, caution should be exercised when using the medication during pregnancy.

    Patients should avoid consuming alcoholic beverages while on a course of Amrizole treatment, as it may lead to abdominal distress, vomiting, flushing, or headache.

    Presentation

    Amrizole is available in the following presentations:

  • Box containing 2 strips, 10 tablets each
  • Bottle of 120 ml oral suspension (shake well before use).

    • Conclusion

    Amrizole is a powerful medication used to treat various infections caused by protozoa and anaerobic bacteria. Its active ingredient, metronidazole, provides effective relief for conditions like trichomoniasis, amoebiasis, giardiasis, and postoperative anaerobic infections. While the medication is generally well-tolerated, it is crucial to follow the prescribed dosage and consult with a healthcare professional before use, especially for pregnant individuals and those with specific medical conditions. By adhering to the treatment guidelines, patients can experience successful outcomes and improved health.

    أمريزول أقراص AMRIZOLE TABLET

  • نشرة أمريزول عربي
  • نشرة أمريزول انجلش

    • التصنيف: ميترونيدازول


    السابق
    Amebazole – Anti-Protozoal Drug –
     التالي
    أدوية الصداع النصفي: أميجران أدكو أقراص فموية –