Clarex (Clarithromycin) is an antibiotic included in the family of macrolides.
Indications
Clarex is indicated in the treatment of infections caused by susceptible organisms. Indications include: Respiratory-tract infections, mild to moderate skin and soft tissue infections, otitis media and Helicobacter pylori eradication.
Dosage And Administration
Respiratory tract/skin and soft tissue infections Adults: The usual dose is 250mg twice daily for 7 days, although this may be increased to 500mg twice daily for up to 14 days in severe infections.
Children older than 12 years: As for adults.
Eradication of H pylori in patients with duodenal ulcer Adults:
TRIPLE THERAPY: Clarex 500mg twice daily should be given with amoxycillin 1000mg twice daily and omeprazole 20mg daily for 10 days.
Elderly: As for adults.
Renal Impairment: Dosage adjustments are not usually required except in patients with severe renal impairment (creatinine clearance <30ml/min). If adjustment is necessary, the total daily dosage should be reduced by half, e.g., 250mg once daily or 250mg twice daily in more severe infections.
Clarex may be given without regard to meals as food does not affect the extent of bioavailability.
Composition
Inactive Ingredients: Corn starch, Avcel 102, Povidone, Aerosil, Sodium starch Glycolate Talc, Magnesium stearate. Croscarmellose, Opadry, Vanilla flavour.
Contraindications
Clarithromycin is contraindicated in patients hyper sensitive to macrolides. Pregnancy. Breast feeding. Severe liver insufficiency.
Precautions
Clarithromycin, is principally excreted by the liver and kidney. Caution should be exercised in adminis trating this antibiotic to patients with impaired hepatic or renal function.
Prolonged or repeated use of Clarex may result in an overgrowth of non susceptible bacteria or fungi.
If super-infection occurs, Clarex should be discontinued and appropriate therapy instituted. H. pylori organisms may develop resistance to clarithromycin in a small number of patients.
Interactions
Side Effects
After oral administration of clarithromycin, some cases of G.l. disturbances have been reported (nausea, heartburns, abdominal pain, diarrhea), headache and skin rashes.
Using macrolides, transient increase of SGOT SGPT are possible, normally reversible after therapy withdrawal.
While during clinical studies with clarithromycin more severe problems relevant to the liver have not been experienced, it should be taken into account that with antibiotics of this family, episodes of cholestatic hepatitis can exceptionally happen.
Like with other antibiotics during therapy with clarithromycin super-infections by resistant bacteria or fungi can rarely arise, needing drug withdrawal and adoption of suitable therapies.
Also reported, dyspepsia, smell and taste disturbances, tooth and tongue discoloration, stomatitis, glossitis, pancreatitis, arthralgia, myalgia, dizziness, vertigo, tinnitus, anxiety, insomnia, nightmares, confusion, psychosis, convulsions, paraesthesia, hypoglycaemia, hepatitis, renal failure, leucopenia and thrombocytopenia.
Over dosage
Reports indicate that the ingestion of large amounts of clarithromycin can be expected to produce gastro-intestinal symptoms. Allergic reactions accompanying over dosage should be treated by gastric lavage and supportive measures.
One patient who has a history of bipolar disorder ingested 8 grams of clarithromycin and showed altered mental status, paranoid behaviour, hypo kalemia and hypoxemia. As with other macrolides, clarithromycin serum levels are not expected to be affected by haemodialysis or peritoneal dialysis.
Other Information
Packaging
Clarex 250 & 500: Boxes of 14 film coated tablets of 250mg and 500mg each.
Storage
Store below 30°C. Do not use this drug after the expiry date given on the package.
THIS IS A MEDICAMENT
A drug is a product which acts on your health and its consumption could be dangerous when you do not follow the instructions. Follow strictly the doctor’s prescriptions, the method of use and the instructions of the pharmacist who sold the medicament.
The doctor and the pharmacist know the medicine, its benefits and risks. Do not by yourself interrupt the period of treatment prescribed for you. Do not repeat the same prescription without consulting your doctor. Keep out of the reach of children.
كلاركس أقراص CLAREX TABLET
CLAREX TABLET -PATIENT INFORMATION LEAFLET
النشرة الداخلية كلاركس أقراص
كلاركس۲٥۰ أو٥۰۰ ميلليجرام أقراص فموية مضاد حيوي واسع المجال
كلاركس ۲٥۰ مجم ٥۰۰ محم كلاريثرومايسين مضاد حيوي من عائلة الماكروليدات
