COMPOSITION
CLINICAL PHARMACOLOGY
Doxazosin Mesylate is a quinazoline derivative postsynaptic alpha1 adrenergic blocking agent. In patients with symptomatic benign prostatic hyperplasia (BPH), urodynamics and symptoms are improved by the use of DOXAGEN, this is due to selective blockade of alpha1-receptors in muscles of prostate and neck of the bladder.
In hypertension, Doxazosin competitively inhibits postsynaptic alpha-adrenergic receptors, which results in vasodilation of veins and arterioles and a decrease in total peripheral resistance and blood pressure.
Clinical studies in hypertensives have shown that doxazosin produces slight plasma concentration reductions in triglycerides and total cholesterol as well as LDL fraction.
Treatment with DOXAGEN has been shown to result in regression of left ventricular hypertrophy as well as an improved insulin sensitivity in patients with such impairment.
دوكساجين اقراص by pharmacia1
INDICATIONS
DOXAGEN is indicated in the treatment of:
CONTRAINDICATIONS
Hypersensitivity to the doxazosin or other gurnazolnes such as: prazosin, terazosin or any component of the formulation.
PRECAUTIONS
ADVERSE REACTIONS
Postural hypotension, dizziness. Headache, somnolence, nausea, diarrhoea, dry mouth, dyspepsia, vomiting, oedema, rash. pruritus. vertigo. fatigue. asthenia, rhinitis, less frequently abdominal discomfort, agitation, tremor rarely blurred vision, thrombocytopenia. purpura, leucopenia, hepatitis, jaundice, cholestasis. urinary Incontinence, isolated cases of priapism and impotence reported.
DRUG INTERACTIONS
Enhanced hypotensive effect may occur when DOXAGEN is co-administered with beta-blockers, diuretics, angiotensin converting enzyme inhibitors. calcium channel blockers and other antihypertensive drugs.
Nonsteroidal anti-inflammatory drugs and phosphodiesterase type 5 inhibitors such as: Sildenafil may antagonize the hypotensive effect of DOXAGEN.
USE DURING PREGNANCY AND LACTATION
There are no adequate and controlled studies for the use of doxazosin in pregnant and nursing women, so DOXAGEN should be used only if clearly necessary during pregnancy and lactation.
DOSAGE
Dosage must be individualized depending on the individual patient’s response.
Benign Prostate Hyperplasia dosage:
The following dosage schedule with DOXAGEN 1 mg is recommended for the start of treatment:
Hypertension dosage
The initial dosage of DOXAGEN is 1 mg once daily. Depending on the individual patient’s standing blood pressure response, dosage may then be increased to 2 mg and thereafter if necessary to 4 mg, 8 mg and 16 mg to achieve the desired reduction in blood pressure. The recommended titration interval is 1 to 2 weeks. The maximum recommended dose for treatment of hypertension is 16 mg once daily.
OVERDOSAGE
Overdosage should lead to hypotension. the patient should be immediately placed in supine, head down position. Other supportive measures such as IV infusion of fluids should be performed if thought appropriate in individual cases. Since doxazosin is highly protein bound, dialysis is not indicated.
INFORMATION FOR PATIENT
Patients should be made aware of the possibility of syncope and orthostatic symptoms, especially at the initiation of therapy and urged to avoid driving or operate heavy machinery for 24 hours after the first dose, after a dosage increase and after interruption of therapy when treatment is resumed.
STORAGE
Store at room temperature (15 to 25) degrees celsius. Do not use the drug after the expiry date printed on the package.
Patient Information Leaflet
DOXAGEN Patient Information Leafletدوكساجن أقراص النشرة الداخلية
ALTERNATIVES
English Alternatives
DOXAGEN, ELAXICOPA, DURACIN, DOXAZIN, DOXACOR,DOSIN, CARDURA. \Categories and tags: C02CA04, Doxazosin, Alpha-adrenoreceptor antagonists, ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING, ANTIHYPERTENSIVES, CARDIOVASCULAR SYSTEM Medicines.
DOXAGEN- Arabic Information
doxagen- Arabic Information