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Understanding Salazopyrin EN: A Patient’s Guide –

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Salazopyrin EN is a medication designed to address conditions like Rheumatoid Arthritis (RA) and Inflammatory Bowel Diseases (I.B.D.). This guide provides clear and accessible information for patients, simplifying medical terms and offering practical advice.

Indications

What is Salazopyrin EN for?

  • Rheumatoid Arthritis (RA): It acts as a “disease modifying” treatment, showing clinical and hematological responses typically within 4 to 12 weeks.
  • I.B.D. (Ulcerative Colitis, Crohn’s Disease, etc.): Used to manage attacks in adults and children, as well as for prophylaxis against relapses of Ulcerative Colitis.

    • How Salazopyrin EN Helps You

    Salazopyrin EN contains Salicylazosulfapyridine, which, when broken down by colonic bacteria, produces substances with anti-inflammatory, antibacterial, and immunomodulation effects. In RA, it modifies the disease, offering relief over time.

    How should you take Salazopyrin EN?

  • RA Dosage:
  • Start with 1 tablet in the evening for the first week.
  • Gradually increase the dosage over the following weeks.
  • I.B.D. Dosage:
  • Adults: 2-4 tablets, 2-4 times/day based on attack severity.
  • Children: Dosage depends on body weight.

    • Note: Enteric coated tablets must not be crushed and should be taken at regular intervals.

    Common and Most Common Side Effects

    Does Salazopyrin EN have side effects? It may be challenging to differentiate side effects from the disease symptoms. Close monitoring is crucial, and any unusual reactions should be reported to a healthcare professional.

    Important Precautions

    What should you be cautious about?

  • Contraindications: Avoid if hypersensitive to sulfonamides or salicylates or in cases of acute intermittent porphyria.
  • Pregnancy & Lactation: Use under medical supervision, though clinical investigations show no evidence of harmful effects.
  • Drug Interactions: Reduced absorption of folate and digoxin may occur when used with Salazopyrin.

    • Practical Tips and Guidance

    1. Consistent Use:
    2. Take Salazopyrin EN as prescribed for optimal results.
    3. Consultation is Key:
    4. Always consult your physician before altering your medication.
    5. Understanding Pregnancy and Lactation:
    6. While generally safe, use under medical guidance during pregnancy and lactation.
    7. Managing Drug Interactions:
    8. Be aware of potential interactions and report any concerns to your healthcare provider.

    Conclusion

    In conclusion, Salazopyrin EN is a valuable treatment option for RA and I.B.D., offering disease-modifying effects. Understanding its indications, dosage, potential side effects, and necessary precautions empowers patients to make informed decisions about their health. Regular communication with healthcare professionals ensures a personalized and effective treatment journey.

    Salazopyrin PRODUCT SUMMARY

  • Composition: Each tablet contains 0.5gm of Salicylazosulfapyridine.

  • Properties: Salicylazosulfapyridine is broken down into 5-aminosalicylic acid and sulfapyridine by colonic bacteria, exhibiting anti-inflammatory, antibacterial, and immunomodulation effects.

  • Indications & Dosage: Rheumatoid Arthritis (RA)

  • Disease-modifying action in RA.
  • Clinical response seen after 4 weeks, may be delayed up to 12 weeks.
  • No analgesic activity; Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) or analgesic doses should not be abruptly reduced until clinical response is achieved.
  • Dosage:
  • 1st week: 1 tablet in the evening.
  • 2nd week: 1 tablet in the morning and evening.
  • 3rd week: 1 tablet in the morning and 2 tablets in the evening.
  • 4th week: 2 tablets in the morning and evening.
  • Note: Only the enteric coated tablet form (EN-tabs.) is indicated for RA.

  • Indications & Dosage: Inflammatory Bowel Diseases (I.B.D.)

  • Adult dosage: 2-4 tabs, 2-4 times/day based on attack severity.
  • Children: 40-60 mg/kg body weight/day divided into 3-6 doses.
  • Prophylaxis against relapses of Ulcerative Colitis: 2 tabs, 2 times daily as maintenance therapy.
  • Note: Enteric Coated tabs. should not be crushed or broken and must be taken at regular intervals.

  • Contra-Indications:

  • Hypersensitivity to sulfonamides or salicylates.
  • Acute intermittent porphyria.

  • Adverse Reactions:

  • Evaluation of adverse reactions may be challenging as symptoms may overlap with I.B.D. disease.

  • Use in Pregnancy & Lactation:

  • Clinical investigations show no evidence of ill effects on the fetus.
  • Negligible drug secretion in breast milk.
  • Use under medical supervision.

  • Drug Interactions:

  • Reduced absorption of folate and digoxin reported when used concomitantly with Salazopyrin.

  • Packing: Boxes of 20 Enteric Coated tablets.

    • SALAZOPYRIN EN TABLET PATIENT INFORMATION LEAFLET PAGE 1تنزيلSALAZOPYRIN EN TABLET PATIENT INFORMATION LEAFLET PAGE 2تنزيلSALAZOPYRIN EN TABLET سالازوبيرين اقراصSALAZOPYRINE


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