Composition: Each 5 ml (teaspoonful) of Zincorhea Syrup contains: 

Active Ingredient: Zinc sulphate monohydrate 54.88 mg (equivalent to 20 mg zinc). 

Inactive Ingredients : Sucrose, Propylene glycol, Methylparaben, Propylparaben, Saccharin sodium, Sodium cyclamate, Sorbitol, Citric acid anhydrous, Sodium citrate dihydrate. Povidone K30 , FD & C yellow, Orange flavour powder, Orange juice flavour, Purified water. 

Indications

Zinc sulphate is a source of zinc which is an essential trace element and involved in a number of body enzyme systems. Zincorhea is used for:

The treatment of zinc deficiency.

The treatment of childhood diarrhoea. 

Dosage & method of administration 

For treatment of zinc deficiency : 

Adults and children more than 30 kg : Two teaspoonfuls once to three times daily after meals. 

Children from 10 30 kg : One teaspoonful once to three times daily after meals.

Children less than 10 kg : One teaspoonful once daily after meals. 

For treatment of diarrhoea:

For infants below 6 months: Half teaspoonful once daily after meals for 14 days.

Children from 6 months/below 5 years: One teaspoonful once daily after meals for 14 days. 

Contraindications 

Hypersensitivity to any of the components of the syrup.

Warnings and Precautions 

Accumulation of zinc may occur in acute renal failure. 

This product contains sorbitol, therefore patients with rare hereditary problems of fructose intolerance should not take this medicine.

Drug Interactions 

Tetracycline Antibacterials : Zinc may reduce the absorption of concurrently administered tetracyclines, also the absorption of zinc may be reduced by tetracyclines; when both are being given an interval of at least three hours should be allowed.

Ouinolone Antibacterials : Zinc may reduce the absorption of quinolones(ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin). 

Calcium salts : The absorption of zinc may be reduced by calcium salts.

Iron : The absorption of zinc may be reduced by oral iron, also the absorption of iron may be reduced by zinc.

Penicillamine : The absorption of zinc may be reduced by penicillamine. also the absorption of penicillamine may be reduced by zinc.

Trientine : The absorption of zinc may be reduced by trientine, also the absorption of trientine may be reduced by zinc.

Pregnancy and lactation 

The safety of zinc in human pregnancy has not been established_ Zinc crosses the placenta and is present in breast milk. 

Effects on ability to drive and use machines 

Zincorhea Syrup is not expected to affect the ability to drive and use machines.

Undesirable effects 

Zinc salts may cause abdominal pain, dyspepsia, nausea, vomiting, diarrhoea, gastric irritation and gastritis. There have also been cases of headache, and lethargy observed.

Overdose

Zinc sulfate is corrosive in overaosage. Symptoms are corrosion and inflammation of the mucous membrane of the mouth and stomach; ulceration of the stomach followed by perforation may occur. Gastric lavage and emesis should be avoided. Demulcents such as milk should be given. Chelating agents such as sodium calcium edetate may be useful.

Pharmacological properties 

Pharmacodynamic properties: Zinc is an essential trace element involved in many enzyme systems. Severe deficiency causes skin lesions. alopecia, diarrhoea, increased susceptibility to infections and failure to thrive in children. Symptoms of less severe deficiency include distorted or absent perceptions of taste and smell and poor wound healing. 

Pharmacokinetic properties : Zinc is absorbed from the gastrointestinal tract and distributed throughout the body. The highest concentrations occur in hair, eyes, male reproductive organs and bone. Lower levels are present in liver, kidney and muscle. In blood 80% is found in erythrocytes. Plasma zinc levels range from 70 to 110 microg/gL and about 50% of this is loosely bound to albumin. About 7% is amino-acid bound and the rest is tightly bound to alpha 2-macroglobulins and other proteins. 

Packing: A carton box containing an amber brown transparent plastic (PET) bottle of 80 ml with white (HDPE) plastic cap and insert leaflet. 

Storage : Store at temperature not exceeding 30° C. Keep out of the reach of children. 

Shelf life : 3 years. 

Produced by : Pharco Pharmaceuticals.

Patient Information Leaflet

 

Product ID

Name Zincorhea Pharmaceutical form Syrup Manufacture Company Pharco Pharmaceuticals. Production & Marketing Company Pharco Pharmaceuticals. Country Egypt Active Ingredient  Zinc sulphate monohydrate Anatomical main group ALIMENTARY TRACT AND METABOLISM Therapeutic subgroup MINERAL SUPPLEMENTS Pharmacological subgroup- 1 OTHER MINERAL SUPPLEMENTS Chemical subgroup Zinc ATC code A12CB01 Product Name in Arabic زنكوريا شراب

Zincorhea Syrup- Arabic Patient Information Leaflet